Played with 6. Two people controlling characters alone and two pairs. Took two weekends to beat. We wore lab coats, drank CDC coffee, and had an utter blast. You need a regular group- doesn’t work drop in-drop out, but if you have at least 2 buddies (up to five with what we did would probably be max I’d suggest, but two of my gaming group are blind so it was great to buddy up) I cannot reccomend this enough. GOTY. Easily.